A secondary mutation in BRAF confers resistance to RAF inhibition in a BRAF V600E-mutant brain tumor

BRAF V600E hyperactivates ERK and signals as a RAF inhibitor-sensitive monomer. While RAF inhibitors can produce impressive clinical responses in patients with mutant BRAF tumors, the mechanisms of resistance to these drugs are incompletely characterized. Here, we report a complete response followed...

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Detalhes bibliográficos
Publicado no:Cancer Discov
Main Authors: Wang, Jiawan, Yao, Zhan, Jonsson, Philip, Allen, Amy N., Qin, Alice Can Ran, Uddin, Sharmeen, Dunkel, Ira J., Petriccione, Mary, Manova, Katia, Haque, Sofia, Rosenblum, Marc K., Pisapia, David J., Rosen, Neal, Taylor, Barry S., Pratilas, Christine A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6125191/
https://ncbi.nlm.nih.gov/pubmed/29880583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-17-1263
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