IL-6 mediates cross-talk between tumor cells and activated fibroblasts in the tumor microenvironment

The tumor microenvironment (TME) plays a major role in the pathogenesis of multiple cancer types, including upper-gastrointestinal (GI) cancers that currently lack effective therapeutic options. Cancer-associated fibroblasts (CAF) are an essential component of the TME, contributing to tumorigenesis...

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Pubblicato in:Cancer Res
Autori principali: Karakasheva, Tatiana A., Lin, Eric W., Tang, Qiaosi, Qiao, Edmund, Waldron, Todd J., Soni, Monica, Klein-Szanto, Andres J., Sahu, Varun, Basu, Devraj, Ohashi, Shinya, Baba, Kiichiro, Giaccone, Zachary T., Walker, Sarah R., Frank, David A., Wileyto, E. Paul, Long, Qi, Dunagin, Margaret C., Raj, Arjun, Diehl, J. Alan, Wong, K. K., Bass, Adam J., Rustgi, Anil K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6125177/
https://ncbi.nlm.nih.gov/pubmed/29976575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-17-2268
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