Distinct prophase arrest mechanisms in human male meiosis

To prevent chromosomal aberrations being transmitted to the offspring, strict meiotic checkpoints are in place to remove aberrant spermatocytes. However, in about 1% of males these checkpoints cause complete meiotic arrest leading to azoospermia and subsequent infertility. Here, we unravel two clear...

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Udgivet i:Development
Main Authors: Jan, Sabrina Z., Jongejan, Aldo, Korver, Cindy M., van Daalen, Saskia K. M., van Pelt, Ans M. M., Repping, Sjoerd, Hamer, Geert
Format: Artigo
Sprog:Inglês
Udgivet: The Company of Biologists Ltd 2018
Fag:
Human Development
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6124541/
https://ncbi.nlm.nih.gov/pubmed/29540502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.160614
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