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TCRαβ/CD3 disruption enables CD3-specific antileukemic T cell immunotherapy
T cells engineered to express chimeric antigen receptors (CARs) against B cell antigens are being investigated as cellular immunotherapies. Similar approaches designed to target T cell malignancies have been hampered by the critical issue of T-on-T cytotoxicity, whereby fratricide or self-destructio...
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| Publicado no: | JCI Insight |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6124532/ https://ncbi.nlm.nih.gov/pubmed/29997304 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.99442 |
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