Dysregulation of the epigenetic landscape of normal aging in Alzheimer’s disease

Aging is the strongest risk factor for Alzheimer’s disease (AD), although the underlying mechanisms remain unclear. The chromatin state, in particular through the mark H4K16ac, has been implicated in aging and thus may play a pivotal role in age-associated neurodegeneration. Here we compare the geno...

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Опубликовано в: :Nat Neurosci
Главные авторы: Nativio, Raffaella, Donahue, Greg, Berson, Amit, Lan, Yemin, Amlie-Wolf, Alexander, Tuzer, Ferit, Toledo, Jon B., Gosai, Sager J., Gregory, Brian D., Torres, Claudio, Trojanowski, John Q., Wang, Li-San, Johnson, F. Brad, Bonini, Nancy M., Berger, Shelley L.
Формат: Artigo
Язык:Inglês
Опубликовано: 2018
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6124498/
https://ncbi.nlm.nih.gov/pubmed/29507413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41593-018-0101-9
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