Krüppel-like factor 4 is a negative regulator of STAT3-induced glomerular epithelial cell proliferation

Pathologic glomerular epithelial cell (GEC) hyperplasia is characteristic of both rapidly progressive glomerulonephritis (RPGN) and subtypes of focal segmental glomerulosclerosis (FSGS). Although initial podocyte injury resulting in activation of STAT3 signals GEC proliferation in both diseases, mec...

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Pubblicato in:JCI Insight
Autori principali: Estrada, Chelsea C., Paladugu, Praharshasai, Guo, Yiqing, Pace, Jesse, Revelo, Monica P., Salant, David J., Shankland, Stuart J., D’Agati, Vivette D., Mehrotra, Anita, Cardona, Stephanie, Bialkowska, Agnieszka B., Yang, Vincent W., He, John C., Mallipattu, Sandeep K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2018
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6124441/
https://ncbi.nlm.nih.gov/pubmed/29925693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.98214
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