The RUNX1/IL-34/CSF-1R axis is an autocrinally regulated modulator of resistance to BRAF-V600E inhibition in melanoma

Resistance to current therapies still impacts a significant number of melanoma patients and can be regulated by epigenetic alterations. Analysis of global cytosine methylation in a cohort of primary melanomas revealed a pattern of early demethylation associated with overexpression of oncogenic trans...

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Pubblicato in:JCI Insight
Autori principali: Giricz, Orsi, Mo, Yongkai, Dahlman, Kimberly B., Cotto-Rios, Xiomaris M., Vardabasso, Chiara, Nguyen, Hoa, Matusow, Bernice, Bartenstein, Matthias, Polishchuk, Veronika, Johnson, Douglas B., Bhagat, Tushar D., Shellooe, Rafe, Burton, Elizabeth, Tsai, James, Zhang, Chao, Habets, Gaston, Greally, John M., Yu, Yiting, Kenny, Paraic A., Fields, Gregg B., Pradhan, Kith, Stanley, E. Richard, Bernstein, Emily, Bollag, Gideon, Gavathiotis, Evripidis, West, Brian L., Sosman, Jeffrey A., Verma, Amit K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2018
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6124424/
https://ncbi.nlm.nih.gov/pubmed/30046005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.120422
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