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CaMKIIδ-mediated inflammatory gene expression and inflammasome activation in cardiomyocytes initiate inflammation and induce fibrosis

Inflammation accompanies heart failure and is a mediator of cardiac fibrosis. CaMKIIδ plays an essential role in adverse remodeling and decompensation to heart failure. We postulated that inflammation is the mechanism by which CaMKIIδ contributes to adverse remodeling in response to nonischemic inte...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Willeford, Andrew, Suetomi, Takeshi, Nickle, Audrey, Hoffman, Hal M., Miyamoto, Shigeki, Heller Brown, Joan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6124412/
https://ncbi.nlm.nih.gov/pubmed/29925681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.97054
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