Androgen excess in pancreatic β cells and neurons predisposes female mice to type 2 diabetes

Androgen excess predisposes women to type 2 diabetes (T2D), but the mechanism of this is poorly understood. We report that female mice fed a Western diet and exposed to chronic androgen excess using dihydrotestosterone (DHT) exhibit hyperinsulinemia and insulin resistance associated with secondary p...

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Veröffentlicht in:JCI Insight
Hauptverfasser: Navarro, Guadalupe, Allard, Camille, Morford, Jamie J., Xu, Weiwei, Liu, Suhuan, Molinas, Adrien J.R., Butcher, Sierra M., Fine, Nicholas H.F., Blandino-Rosano, Manuel, Sure, Venkata N., Yu, Sangho, Zhang, Rui, Münzberg, Heike, Jacobson, David A., Katakam, Prasad V., Hodson, David J., Bernal-Mizrachi, Ernesto, Zsombok, Andrea, Mauvais-Jarvis, Franck
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2018
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6124401/
https://ncbi.nlm.nih.gov/pubmed/29925687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.98607
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