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Androgen Excess Produces Systemic Oxidative Stress and Predisposes to β-Cell Failure in Female Mice

In women, excess production of the male hormone, testosterone (T), is accompanied by insulin resistance. However, hyperandrogenemia is also associated with β-cell dysfunction and type 2 diabetes raising the possibility that androgen receptor (AR) activation predisposes to β-cell failure. Here, we te...

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Autors principals: Liu, Suhuan, Navarro, Guadalupe, Mauvais-Jarvis, Franck
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2892018/
https://ncbi.nlm.nih.gov/pubmed/20585581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0011302
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