Repurposing sertraline sensitizes non–small cell lung cancer cells to erlotinib by inducing autophagy

Lung cancer patients treated with tyrosine kinase inhibitors (TKIs) often develop resistance. More effective and safe therapeutic agents are urgently needed to overcome TKI resistance. Here, we propose a medical genetics–based approach to identify indications for over 1,000 US Food and Drug Administ...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Jiang, Xingwu, Lu, Weiqiang, Shen, Xiaoyang, Wang, Quan, Lv, Jing, Liu, Mingyao, Cheng, Feixiong, Zhao, Zhongming, Pang, Xiufeng
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6124398/
https://ncbi.nlm.nih.gov/pubmed/29875309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.98921
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