Inhibition of histone deacetylases sensitizes EGF receptor‐TK inhibitor‐resistant non‐small‐cell lung cancer cells to erlotinib in vitro and in vivo

BACKGROUND AND PURPOSE: Intrinsic and/or acquired resistance of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) commonly occurs in patients with non‐small‐cell lung cancer (NSCLC). Here, we developed a combined therapy of histone deacetylase inhibition by a novel HDAC inhib...

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Veröffentlicht in:Br J Pharmacol
Hauptverfasser: Yu, Weiwei, Lu, Weiqiang, Chen, Guoliang, Cheng, Feixiong, Su, Hui, Chen, Yihua, Liu, Mingyao, Pang, Xiufeng
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2017
Schlagworte:
Research Papers
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5610149/
https://ncbi.nlm.nih.gov/pubmed/28749535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13961
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