Yes-associated protein (YAP) binds to HIF-1α and sustains HIF-1α protein stability to promote hepatocellular carcinoma cell glycolysis under hypoxic stress

BACKGROUND: Hypoxia-inducible factor 1α (HIF-1α) is essential in hepatocellular carcinoma (HCC) glycolysis and progression. Yes-associated protein (YAP) is a powerful regulator and is overexpressed in many cancers, including HCC. The regulatory mechanism of YAP and HIF-1α in HCC glycolysis is unknow...

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Bibliographic Details
Published in:	J Exp Clin Cancer Res
Main Authors:	Zhang, Xiaodong, Li, Yan, Ma, Yingbo, Yang, Liang, Wang, Tao, Meng, Xin, Zong, Zhihong, Sun, Xun, Hua, Xiangdong, Li, Hangyu
Format:	Artigo
Language:	Inglês
Published:	BioMed Central 2018
Subjects:	Research
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC6123950/ https://ncbi.nlm.nih.gov/pubmed/30180863 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-018-0892-2
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Yes-associated protein (YAP) binds to HIF-1α and sustains HIF-1α protein stability to promote hepatocellular carcinoma cell glycolysis under hypoxic stress

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