Serine Phosphorylation by mTORC1 Promotes IRS-1 Degradation through SCFβ-TRCP E3 Ubiquitin Ligase

The insulin receptor substrate IRS-1 is a key substrate of insulin and insulin-like growth factor (IGF) receptor tyrosine kinases that mediates their metabolic and growth-promoting actions. Proteasomal degradation of IRS-1 is induced following activation of the downstream kinase mTOR complex 1 (mTOR...

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Publicado no:iScience
Main Authors: Yoneyama, Yosuke, Inamitsu, Tomomi, Chida, Kazuhiro, Iemura, Shun-Ichiro, Natsume, Tohru, Maeda, Tatsuya, Hakuno, Fumihiko, Takahashi, Shin-Ichiro
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6123863/
https://ncbi.nlm.nih.gov/pubmed/30240640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2018.06.006
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