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The hemochromatosis protein HFE signals predominantly via the BMP type I receptor ALK3 in vivo

Mutations in HFE, the most common cause of hereditary hemochromatosis, lead to iron overload. The iron overload is characterized by increased iron uptake due to lower levels of the hepatic, iron regulatory hormone hepcidin. HFE was cloned 21 years ago, but the signaling pathway is still unknown. Bec...

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書目詳細資料
發表在:Commun Biol
Main Authors: Traeger, Lisa, Enns, Caroline A., Krijt, Jan, Steinbicker, Andrea U.
格式: Artigo
語言:Inglês
出版: Nature Publishing Group UK 2018
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6123693/
https://ncbi.nlm.nih.gov/pubmed/30271947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-018-0071-1
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