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The hemochromatosis protein HFE signals predominantly via the BMP type I receptor ALK3 in vivo
Mutations in HFE, the most common cause of hereditary hemochromatosis, lead to iron overload. The iron overload is characterized by increased iron uptake due to lower levels of the hepatic, iron regulatory hormone hepcidin. HFE was cloned 21 years ago, but the signaling pathway is still unknown. Bec...
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| I publikationen: | Commun Biol |
|---|---|
| Huvudupphovsmän: | , , , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
Nature Publishing Group UK
2018
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6123693/ https://ncbi.nlm.nih.gov/pubmed/30271947 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-018-0071-1 |
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