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Towards understanding aromatase inhibitory activity via QSAR modeling

Aromatase is a rate-limiting enzyme for estrogen biosynthesis that is overproduced in breast cancer tissue. To block the growth of breast tumors, aromatase inhibitors (AIs) are employed to bind and inhibit aromatase in order to lower the amount of estrogen produced in the body. Although a number of...

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Bibliographic Details
Published in:EXCLI J
Main Authors: Shoombuatong, Watshara, Schaduangrat, Nalini, Nantasenamat, Chanin
Format: Artigo
Language:Inglês
Published: Leibniz Research Centre for Working Environment and Human Factors 2018
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6123608/
https://ncbi.nlm.nih.gov/pubmed/30190660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.17179/excli2018-1417
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