Probing the origins of aromatase inhibitory activity of disubstituted coumarins via QSAR and molecular docking

This study investigated the quantitative structure-activity relationship (QSAR) of imidazole derivatives of 4,7-disubstituted coumarins as inhibitors of aromatase, a potential therapeutic protein target for the treatment of breast cancer. Herein, a series of 3,7- and 4,7-disubstituted coumarin deriv...

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Bibliographic Details
Published in:EXCLI J
Main Authors: Worachartcheewan, Apilak, Suvannang, Naravut, Prachayasittikul, Supaluk, Prachayasittikul, Virapong, Nantasenamat, Chanin
Format: Artigo
Language:Inglês
Published: Leibniz Research Centre for Working Environment and Human Factors 2014
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4463968/
https://ncbi.nlm.nih.gov/pubmed/26417339
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