Structural and biochemical insights into small RNA 3′ end trimming by Arabidopsis SDN1

A family of DEDDh 3′→5′ exonucleases known as Small RNA Degrading Nucleases (SDNs) initiates the turnover of ARGONAUTE1 (AGO1)-bound microRNAs in Arabidopsis by trimming their 3′ ends. Here, we report the crystal structure of Arabidopsis SDN1 (residues 2-300) in complex with a 9 nucleotide single-st...

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Udgivet i:Nat Commun
Main Authors: Chen, Jiayi, Liu, Li, You, Chenjiang, Gu, Jiaqi, Ruan, Wenjie, Zhang, Lu, Gan, Jianhua, Cao, Chunyang, Huang, Ying, Chen, Xuemei, Ma, Jinbiao
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6123492/
https://ncbi.nlm.nih.gov/pubmed/30181559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05942-7
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