Identification of non-mutated neoantigens presented by TAP-deficient tumors

Most T cell–based immunotherapies of cancer depend on intact antigen presentation by HLA class I molecules (HLA-I). However, defects in the antigen-processing machinery can cause downregulation of HLA-I, rendering tumor cells resistant to CD8(+) T cells. Previously, we demonstrated that a unique cat...

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Dades bibliogràfiques
Publicat a:J Exp Med
Autors principals: Marijt, Koen A., Blijleven, Laura, Verdegaal, Els M.E., Kester, Michel G., Kowalewski, Daniel J., Rammensee, Hans-Georg, Stevanović, Stefan, Heemskerk, Mirjam H.M., van der Burg, Sjoerd H., van Hall, Thorbald
Format: Artigo
Idioma:Inglês
Publicat: Rockefeller University Press 2018
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6122969/
https://ncbi.nlm.nih.gov/pubmed/30115740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20180577
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