HNF1A is a novel oncogene that regulates human pancreatic cancer stem cell properties

The biological properties of pancreatic cancer stem cells (PCSCs) remain incompletely defined and the central regulators are unknown. By bioinformatic analysis of a human PCSC-enriched gene signature, we identified the transcription factor HNF1A as a putative central regulator of PCSC function. Leve...

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Vydáno v:eLife
Hlavní autoři: Abel, Ethan V, Goto, Masashi, Magnuson, Brian, Abraham, Saji, Ramanathan, Nikita, Hotaling, Emily, Alaniz, Anthony A, Kumar-Sinha, Chandan, Dziubinski, Michele L, Urs, Sumithra, Wang, Lidong, Shi, Jiaqi, Waghray, Meghna, Ljungman, Mats, Crawford, Howard C, Simeone, Diane M
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2018
Témata:
Cancer Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6122955/
https://ncbi.nlm.nih.gov/pubmed/30074477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.33947
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