cGMP Imaging in Brain Slices Reveals Brain Region-Specific Activity of NO-Sensitive Guanylyl Cyclases (NO-GCs) and NO-GC Stimulators

Impaired NO-cGMP signaling has been linked to several neurological disorders. NO-sensitive guanylyl cyclase (NO-GC), of which two isoforms—NO-GC1 and NO-GC2—are known, represents a promising drug target to increase cGMP in the brain. Drug-like small molecules have been discovered that work synergist...

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Veröffentlicht in:Int J Mol Sci
Hauptverfasser: Peters, Stefanie, Paolillo, Michael, Mergia, Evanthia, Koesling, Doris, Kennel, Lea, Schmidtko, Achim, Russwurm, Michael, Feil, Robert
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6122017/
https://ncbi.nlm.nih.gov/pubmed/30087260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms19082313
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