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Spare guanylyl cyclase NO receptors ensure high NO sensitivity in the vascular system
In the vascular system, the receptor for the signaling molecule NO, guanylyl cyclase (GC), mediates smooth muscle relaxation and inhibition of platelet aggregation by increasing intracellular cyclic GMP (cGMP) concentration. The heterodimeric GC exists in 2 isoforms (α(1)-GC, α(2)-GC) with indisting...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1435723/ https://ncbi.nlm.nih.gov/pubmed/16614755 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI27657 |
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