Somatic TP53 Mutations Are Detectable in Circulating Tumor DNA from Children with Anaplastic Wilms Tumors()()

BACKGROUND: Diffuse anaplastic Wilms tumor (DAWT) is a rare, high-risk subtype that is often missed on diagnostic needle biopsy. Somatic mutations in TP53 are associated with the development of anaplasia and with poorer survival, particularly in advanced-stage disease. Early identification of DAWT h...

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Vydáno v:Transl Oncol
Hlavní autoři: Treger, Taryn D., Chagtai, Tasnim, Butcher, Robert, Cresswell, George D., Al-Saadi, Reem, Brok, Jesper, Williams, Richard D., Roberts, Chrissy, Luscombe, Nicholas M., Pritchard Jones, Kathy, Mifsud, William
Médium: Artigo
Jazyk:Inglês
Vydáno: Neoplasia Press 2018
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Original article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6121832/
https://ncbi.nlm.nih.gov/pubmed/30172241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tranon.2018.08.006
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