Nucleotide Composition of Human Ig Nontemplated Regions Depends on Trimming of the Flanking Gene Segments, and Terminal Deoxynucleotidyl Transferase Favors Adding Cytosine, Not Guanosine, in Most VDJ Rearrangements

The formation of nontemplated (N) regions during Ig gene rearrangement is a major contributor to Ab diversity. To gain insights into the mechanisms behind this, we studied the nucleotide composition of N regions within 29,962 unique human V(H)DJ(H) rearrangements and 8728 unique human DJ(H) rearrang...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: Funck, Tina, Barnkob, Mike Bogetofte, Holm, Nanna, Ohm-Laursen, Line, Mehlum, Camilla Slot, Möller, Sören, Barington, Torben
Formato: Artigo
Idioma:Inglês
Publicado em: AAI 2018
Assuntos:
Molecular and Structural Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6121214/
https://ncbi.nlm.nih.gov/pubmed/30097530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1800100
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