Nucleotide Composition of Human Ig Nontemplated Regions Depends on Trimming of the Flanking Gene Segments, and Terminal Deoxynucleotidyl Transferase Favors Adding Cytosine, Not Guanosine, in Most VDJ Rearrangements

The formation of nontemplated (N) regions during Ig gene rearrangement is a major contributor to Ab diversity. To gain insights into the mechanisms behind this, we studied the nucleotide composition of N regions within 29,962 unique human V(H)DJ(H) rearrangements and 8728 unique human DJ(H) rearrang...

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Vydáno v:J Immunol
Hlavní autoři: Funck, Tina, Barnkob, Mike Bogetofte, Holm, Nanna, Ohm-Laursen, Line, Mehlum, Camilla Slot, Möller, Sören, Barington, Torben
Médium: Artigo
Jazyk:Inglês
Vydáno: AAI 2018
Témata:
Molecular and Structural Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6121214/
https://ncbi.nlm.nih.gov/pubmed/30097530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1800100
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