Nucleotide Composition of Human Ig Nontemplated Regions Depends on Trimming of the Flanking Gene Segments, and Terminal Deoxynucleotidyl Transferase Favors Adding Cytosine, Not Guanosine, in Most VDJ Rearrangements

The formation of nontemplated (N) regions during Ig gene rearrangement is a major contributor to Ab diversity. To gain insights into the mechanisms behind this, we studied the nucleotide composition of N regions within 29,962 unique human V(H)DJ(H) rearrangements and 8728 unique human DJ(H) rearrang...

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Bibliographische Detailangaben
Veröffentlicht in:J Immunol
Hauptverfasser: Funck, Tina, Barnkob, Mike Bogetofte, Holm, Nanna, Ohm-Laursen, Line, Mehlum, Camilla Slot, Möller, Sören, Barington, Torben
Format: Artigo
Sprache:Inglês
Veröffentlicht: AAI 2018
Schlagworte:
Molecular and Structural Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6121214/
https://ncbi.nlm.nih.gov/pubmed/30097530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1800100
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