Identification of inactive conformation‐selective interleukin‐2‐inducible T‐cell kinase (ITK) inhibitors based on second‐harmonic generation

Many clinically approved protein kinase inhibitors stabilize an inactive conformation of their kinase target. Such inhibitors are generally highly selective compared to active conformation inhibitors, and consequently, general methods to identify inhibitors that stabilize an inactive conformation ar...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:FEBS Open Bio
Egile Nagusiak: Hantani, Yoshiji, Iio, Kiyosei, Hantani, Rie, Umetani, Kayo, Sato, Toshihiro, Young, Tracy, Connell, Katelyn, Kintz, Sam, Salafsky, Joshua
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: John Wiley and Sons Inc. 2018
Gaiak:
Research Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6120236/
https://ncbi.nlm.nih.gov/pubmed/30186743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/2211-5463.12489
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