Obesity-induced protein carbonylation in murine adipose tissue regulates the DNA-binding domain of nuclear zinc finger proteins

In obesity-linked insulin resistance, oxidative stress in adipocytes leads to lipid peroxidation and subsequent carbonylation of proteins by diffusible lipid electrophiles. Reduction in oxidative stress attenuates protein carbonylation and insulin resistance, suggesting that lipid modification of pr...

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Vydáno v:J Biol Chem
Hlavní autoři: Hauck, Amy K., Zhou, Tong, Hahn, Wendy, Petegrosso, Raphael, Kuang, Rui, Chen, Yue, Bernlohr, David A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2018
Témata:
Metabolism
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6120186/
https://ncbi.nlm.nih.gov/pubmed/30012885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.003469
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