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Prototype foamy virus integrase is promiscuous for target choice

Retroviruses have two essential activities: reverse transcription and integration. The viral protein integrase (IN) covalently joins the viral cDNA genome to the host DNA. Prototype foamy virus (PFV) IN has become a model of retroviral intasome structure. However, this retroviral IN has not been wel...

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Detalhes bibliográficos
Publicado no:Biochem Biophys Res Commun
Main Authors: Mackler, R.M., Lopez, M.A., Osterhage, M.J., Yoder, K.E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6119477/
https://ncbi.nlm.nih.gov/pubmed/30017200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2018.07.031
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