Hyperpolarized (13)C Magnetic Resonance Spectroscopy Reveals the Rate-Limiting Role of the Blood–Brain Barrier in the Cerebral Uptake and Metabolism of l-Lactate in Vivo

[Image: see text] The dynamics of l-lactate transport across the blood–brain barrier (BBB) and its cerebral metabolism are still subject to debate. We studied lactate uptake and intracellular metabolism in the mouse brain using hyperpolarized (13)C magnetic resonance spectroscopy (MRS). Following th...

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Bibliografiske detaljer
Udgivet i:ACS Chem Neurosci
Main Authors: Takado, Yuhei, Cheng, Tian, Bastiaansen, Jessica A. M., Yoshihara, Hikari A. I., Lanz, Bernard, Mishkovsky, Mor, Lengacher, Sylvain, Comment, Arnaud
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2018
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6119468/
https://ncbi.nlm.nih.gov/pubmed/29771492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.8b00066
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