A carregar...

A simple but profound mutation in mouse DNA polymerase ε drives tumorigenesis

Over 40 years ago, Loeb and colleagues proposed that errors in DNA replication produce a mutator phenotype that is involved in generating the multiple mutations required for tumor development. In this issue of the JCI, Li, Castrillon, and colleagues describe a mouse model containing a single base ch...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:J Clin Invest
Autor principal: Kunkel, Thomas A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6118597/
https://ncbi.nlm.nih.gov/pubmed/30124465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI123021
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!