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A simple but profound mutation in mouse DNA polymerase ε drives tumorigenesis
Over 40 years ago, Loeb and colleagues proposed that errors in DNA replication produce a mutator phenotype that is involved in generating the multiple mutations required for tumor development. In this issue of the JCI, Li, Castrillon, and colleagues describe a mouse model containing a single base ch...
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| Pubblicato in: | J Clin Invest |
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| Autore principale: | |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Clinical Investigation
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6118597/ https://ncbi.nlm.nih.gov/pubmed/30124465 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI123021 |
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