Oncogenic TRK fusions are amenable to inhibition in hematologic malignancies

Rearrangements involving the neurotrophic receptor kinase genes (NTRK1, NTRK2, and NTRK3; hereafter referred to as TRK) produce oncogenic fusions in a wide variety of cancers in adults and children. Although TRK fusions occur in fewer than 1% of all solid tumors, inhibition of TRK results in profoun...

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Bibliografiske detaljer
Udgivet i:J Clin Invest
Main Authors: Taylor, Justin, Pavlick, Dean, Yoshimi, Akihide, Marcelus, Christina, Chung, Stephen S., Hechtman, Jaclyn F., Benayed, Ryma, Cocco, Emiliano, Durham, Benjamin H., Bitner, Lillian, Inoue, Daichi, Chung, Young Rock, Mullaney, Kerry, Watts, Justin M., Diamond, Eli L., Albacker, Lee A., Mughal, Tariq I., Ebata, Kevin, Tuch, Brian B., Ku, Nora, Scaltriti, Maurizio, Roshal, Mikhail, Arcila, Maria, Ali, Siraj, Hyman, David M., Park, Jae H., Abdel-Wahab, Omar
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2018
Fag:
Concise Communication
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6118587/
https://ncbi.nlm.nih.gov/pubmed/29920189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI120787
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