The anti-HIV pentameric pseudopeptide HB-19 is preferentially taken up in vivo by lymphoid organs where it forms a complex with nucleolin

The HB-19 pseudopeptide 5[Kψ(CH(2)N)PR]-TASP, ψ(CH(2)N) for reduced peptide bond, is a specific inhibitor of HIV infection in different CD4(+) cell lines and in primary T-lymphocytes and macrophages. It blocks virus-particle attachment to permissive cells by binding and forming a stable complex with...

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Detalhes bibliográficos
Main Authors: Krust, B., Vienet, R., Cardona, A., Rougeot, C., Jacotot, E., Callebaut, C., Guichard, G., Briand, J. P., Grognet, J. M., Hovanessian, A. G., Edelman, L.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2001
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC61173/
https://ncbi.nlm.nih.gov/pubmed/11698640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.221467298
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