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Tryparedoxin peroxidase-deficiency commits trypanosomes to ferroptosis-type cell death
Tryparedoxin peroxidases, distant relatives of glutathione peroxidase 4 in higher eukaryotes, are responsible for the detoxification of lipid-derived hydroperoxides in African trypanosomes. The lethal phenotype of procyclic Trypanosoma brucei that lack the enzymes fulfils all criteria defining a for...
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| Udgivet i: | eLife |
|---|---|
| Main Authors: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
eLife Sciences Publications, Ltd
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6117152/ https://ncbi.nlm.nih.gov/pubmed/30047863 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.37503 |
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