Structural Basis for a Distinct Catalytic Mechanism in Trypanosoma brucei Tryparedoxin Peroxidase

Trypanosoma brucei, the causative agent of African sleeping sickness, encodes three cysteine homologues (Px I-III) of classical selenocysteine-containing glutathione peroxidases. The enzymes obtain their reducing equivalents from the unique trypanothione (bis(glutathionyl)spermidine)/tryparedoxin sy...

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Detalhes bibliográficos
Main Authors: Melchers, Johannes, Diechtierow, Michael, Fehér, Krisztina, Sinning, Irmgard, Tews, Ivo, Krauth-Siegel, R. Luise, Muhle-Goll, Claudia
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2662087/
https://ncbi.nlm.nih.gov/pubmed/18684708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M803563200
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