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Comparison of statistical methods and the use of quality control samples for batch effect correction in human transcriptome data

Batch effects are technical sources of variation introduced by the necessity of conducting gene expression analyses on different dates due to the large number of biological samples in population-based studies. The aim of this study is to evaluate the performances of linear mixed models (LMM) and Com...

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Publicat a:PLoS One
Autors principals: Espín-Pérez, Almudena, Portier, Chris, Chadeau-Hyam, Marc, van Veldhoven, Karin, Kleinjans, Jos C. S., de Kok, Theo M. C. M.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2018
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6117018/
https://ncbi.nlm.nih.gov/pubmed/30161168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0202947
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