An explorative study on deep profiling of peripheral leukocytes to identify predictors for responsiveness to anti-tumour necrosis factor alpha therapies in ankylosing spondylitis: natural killer cells in focus

BACKGROUND: Therapeutic targeting of tumour necrosis factor (TNF)-α is highly effective in ankylosing spondylitis (AS) patients. However, since one-third of anti-TNF-treated AS patients do not show an adequate clinical response there is an urgent need for new biomarkers that would aid clinicians in...

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Détails bibliographiques
Publié dans:Arthritis Res Ther
Auteurs principaux: Schulte-Wrede, Ursula, Sörensen, Till, Grün, Joachim R., Häupl, Thomas, Hirseland, Heike, Steinbrich-Zöllner, Marta, Wu, Peihua, Radbruch, Andreas, Poddubnyy, Denis, Sieper, Joachim, Syrbe, Uta, Grützkau, Andreas
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2018
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6116509/
https://ncbi.nlm.nih.gov/pubmed/30157966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-018-1692-y
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