Tofacitinib inhibits granulocyte–macrophage colony-stimulating factor-induced NLRP3 inflammasome activation in human neutrophils

BACKGROUND: Granulocyte–macrophage colony-stimulating factor (GM-CSF) has emerged as a crucial cytokine that activates myeloid cells to initiate tissue inflammation. However, the molecular actions of GM-CSF against innate immunity are still poorly characterized. Here, we investigated the in vitro ef...

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Gepubliceerd in:Arthritis Res Ther
Hoofdauteurs: Furuya, Makiko Yashiro, Asano, Tomoyuki, Sumichika, Yuya, Sato, Shuzo, Kobayashi, Hiroko, Watanabe, Hiroshi, Suzuki, Eiji, Kozuru, Hideko, Yatsuhashi, Hiroshi, Koga, Tomohiro, Ohira, Hiromasa, Sekine, Hideharu, Kawakami, Atsushi, Migita, Kiyoshi
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2018
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6116484/
https://ncbi.nlm.nih.gov/pubmed/30157949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-018-1685-x
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