Alzheimer-associated cerebrospinal fluid fragments of neurogranin are generated by Calpain-1 and prolyl endopeptidase

BACKGROUND: Neurogranin (Ng) is a small 7.6 kDa postsynaptic protein that has been detected at elevated concentrations in cerebrospinal fluid (CSF) of patients with Alzheimer’s disease (AD), both as a full-length molecule and as fragments from its C-terminal half. Ng is involved in postsynaptic calc...

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Detalhes bibliográficos
Publicado no:Mol Neurodegener
Main Authors: Becker, Bruno, Nazir, Faisal Hayat, Brinkmalm, Gunnar, Camporesi, Elena, Kvartsberg, Hlin, Portelius, Erik, Boström, Martina, Kalm, Marie, Höglund, Kina, Olsson, Maria, Zetterberg, Henrik, Blennow, Kaj
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6116393/
https://ncbi.nlm.nih.gov/pubmed/30157938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-018-0279-z
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