Phosphorylation of Acetyl-CoA Carboxylase by AMPK Reduces Renal Fibrosis and Is Essential for the Anti-Fibrotic Effect of Metformin

BACKGROUND: Expression of genes regulating fatty acid metabolism is reduced in tubular epithelial cells from kidneys with tubulointerstitial fibrosis (TIF), thus decreasing the energy produced by fatty acid oxidation (FAO). Acetyl-CoA carboxylase (ACC), a target for the energy-sensing AMP-activating...

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Detalhes bibliográficos
Publicado no:J Am Soc Nephrol
Main Authors: Lee, Mardiana, Katerelos, Marina, Gleich, Kurt, Galic, Sandra, Kemp, Bruce E., Mount, Peter F., Power, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2018
Assuntos:
Basic Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6115654/
https://ncbi.nlm.nih.gov/pubmed/29976587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2018010050
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