Alpha-6 integrin promotes radioresistance of glioblastoma by modulating DNA damage response and the transcription factor Zeb1

Radiotherapy is the cornerstone of glioblastoma (GBM) standard treatment. However, radioresistance of cancer cells leads to an inevitable recurrence. In the present study, we showed that blocking α6-integrin in cells derived from GBM biopsy specimens cultured as neurospheres, sensitized cells to rad...

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Publicat a:Cell Death Dis
Autors principals: Kowalski-Chauvel, Aline, Modesto, Anouchka, Gouaze-andersson, Valerie, Baricault, Laurent, Gilhodes, Julia, Delmas, Caroline, Lemarie, Anthony, Toulas, Christine, Cohen-Jonathan-Moyal, Elizabeth, Seva, Catherine
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6115442/
https://ncbi.nlm.nih.gov/pubmed/30158599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-0853-x
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