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MYC dephosphorylation by the PP1/PNUTS phosphatase complex regulates chromatin binding and protein stability
The c-MYC (MYC) oncoprotein is deregulated in over 50% of cancers, yet regulatory mechanisms controlling MYC remain unclear. To this end, we interrogated the MYC interactome using BioID mass spectrometry (MS) and identified PP1 (protein phosphatase 1) and its regulatory subunit PNUTS (protein phosph...
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| 出版年: | Nat Commun |
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| 主要な著者: | , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group UK
2018
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6115416/ https://ncbi.nlm.nih.gov/pubmed/30158517 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05660-0 |
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