MYC dephosphorylation by the PP1/PNUTS phosphatase complex regulates chromatin binding and protein stability

The c-MYC (MYC) oncoprotein is deregulated in over 50% of cancers, yet regulatory mechanisms controlling MYC remain unclear. To this end, we interrogated the MYC interactome using BioID mass spectrometry (MS) and identified PP1 (protein phosphatase 1) and its regulatory subunit PNUTS (protein phosph...

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Foilsithe in:Nat Commun
Main Authors: Dingar, Dharmendra, Tu, William B., Resetca, Diana, Lourenco, Corey, Tamachi, Aaliya, De Melo, Jason, Houlahan, Kathleen E., Kalkat, Manpreet, Chan, Pak-Kei, Boutros, Paul C., Raught, Brian, Penn, Linda Z.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group UK 2018
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6115416/
https://ncbi.nlm.nih.gov/pubmed/30158517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05660-0
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