Presenilin 1 deficiency suppresses autophagy in human neural stem cells through reducing γ-secretase-independent ERK/CREB signaling

Autophagy impairment is commonly implicated in the pathological characteristic of Alzheimer’s disease (AD). Presenilin 1 (PS1) expression in human brain gradually decreases with age and its mutations account for the most common cases of early-onset familial Alzheimer’s disease (FAD). The dominant au...

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Vydáno v:Cell Death Dis
Hlavní autoři: Chong, Cheong-Meng, Ke, Minjing, Tan, Yuan, Huang, Zhijian, Zhang, Ke, Ai, Nana, Ge, Wei, Qin, Dajiang, Lu, Jia-Hong, Su, Huanxing
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6115391/
https://ncbi.nlm.nih.gov/pubmed/30158533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-0945-7
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