Novel β-phenylacrylic acid derivatives exert anti-cancer activity by inducing Src-mediated apoptosis in wild-type KRAS colon cancer

Many stress conditions including chemotherapy treatment is known to activate Src and under certain condition Src can induce the apoptotic signal via c-Jun N-terminal kinase (JNK) activation. Here we report that the newly synthesized β-phenylacrylic acid derivatives, MHY791 and MHY1036 (MHYs), bind t...

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Detaylı Bibliyografya
Yayımlandı:Cell Death Dis
Asıl Yazarlar: Kim, Su Jin, Noh, Tae Hwan, Son, Sujin, Kim, Do Hyun, Kim, Wooseong, Lee, Yunna, Choo, Jieun, Heo, Gwangbeom, Kim, Min Jae, Chung, Hae Young, Jung, Yunjin, Jung, Jee Hyung, Moon, Hyung Ryong, Im, Eunok
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2018
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6115383/
https://ncbi.nlm.nih.gov/pubmed/30158525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-0942-x
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