Novel β-phenylacrylic acid derivatives exert anti-cancer activity by inducing Src-mediated apoptosis in wild-type KRAS colon cancer

Many stress conditions including chemotherapy treatment is known to activate Src and under certain condition Src can induce the apoptotic signal via c-Jun N-terminal kinase (JNK) activation. Here we report that the newly synthesized β-phenylacrylic acid derivatives, MHY791 and MHY1036 (MHYs), bind t...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Kim, Su Jin, Noh, Tae Hwan, Son, Sujin, Kim, Do Hyun, Kim, Wooseong, Lee, Yunna, Choo, Jieun, Heo, Gwangbeom, Kim, Min Jae, Chung, Hae Young, Jung, Yunjin, Jung, Jee Hyung, Moon, Hyung Ryong, Im, Eunok
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6115383/
https://ncbi.nlm.nih.gov/pubmed/30158525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-0942-x
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