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New Ru(II) Complex for Dual Photochemotherapy: Release of Cathepsin K Inhibitor and (1)O(2) Production

A new complex, [Ru(tpy)(dppn)(Cbz-Leu-NHCH(2)CN)](2+) (1, tpy = 2,2′:6′,2″-terpyridine, dppn = benzo[i]dipyrido[3,2-a:2′,3′-c]phenazine) was synthesized and its photochemical properties were investigated. This complex undergoes photorelease of the Cbz-Leu-NHCH(2)CN ligand, a known cathepsin K inhibi...

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Detalhes bibliográficos
Publicado no:Dalton Trans
Main Authors: Rohrabaugh, Thomas N., Collins, Kelsey A., Xue, Congcong, White, Jessica K., Kodanko, Jeremy J., Turro, Claudia
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6115277/
https://ncbi.nlm.nih.gov/pubmed/29741184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8dt00876k
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