Characterization and validation of Entamoeba histolytica pantothenate kinase as a novel anti-amebic drug target

The Coenzyme A (CoA), as a cofactor involved in >100 metabolic reactions, is essential to the basic biochemistry of life. Here, we investigated the CoA biosynthetic pathway of Entamoeba histolytica (E. histolytica), an enteric protozoan parasite responsible for human amebiasis. We identified four...

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Veröffentlicht in:Int J Parasitol Drugs Drug Resist
Hauptverfasser: Nurkanto, Arif, Jeelani, Ghulam, Yamamoto, Takehiro, Naito, Yoshiko, Hishiki, Takako, Mori, Mihoko, Suematsu, Makoto, Shiomi, Kazuro, Hashimoto, Tetsuo, Nozaki, Tomoyoshi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6114107/
https://ncbi.nlm.nih.gov/pubmed/29518650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijpddr.2018.02.004
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