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Genetic, metabolomic and transcriptomic analyses of the de novo L-cysteine biosynthetic pathway in the enteric protozoan parasite Entamoeba histolytica

The de novo L-cysteine biosynthetic pathway is critical for the growth, antioxidative stress defenses, and pathogenesis of bacterial and protozoan pathogens, such as Salmonella typhimurium and Entamoeba histolytica. This pathway involves two key enzymes, serine acetyltransferase (SAT) and cysteine s...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Jeelani, Ghulam, Sato, Dan, Soga, Tomoyoshi, Nozaki, Tomoyoshi
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2017
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5688106/
https://ncbi.nlm.nih.gov/pubmed/29142277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-15923-3
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