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Rac1 Nanoscale Organization on the Plasma Membrane Is Driven by Lipid Binding Specificity Encoded in the Membrane Anchor

Rac1 is a small guanine nucleotide binding protein that cycles between an inactive GDP-bound and active GTP-bound state to regulate cell motility and migration. Rac1 signaling is initiated from the plasma membrane (PM). Here, we used high-resolution spatial mapping and manipulation of PM lipid compo...

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Detalhes bibliográficos
Publicado no:Mol Cell Biol
Main Authors: Maxwell, Kelsey N., Zhou, Yong, Hancock, John F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6113602/
https://ncbi.nlm.nih.gov/pubmed/29967243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00186-18
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