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Structural and kinetic studies of the effect of guanine-N7 alkylation and metal cofactors on DNA replication

A wide variety of endogenous and exogenous alkylating agents attack DNA to preferentially generate N7-alkylguanine (N7-alkylG) adducts. Studies on the effect of N7-alkylG lesions on biological processes have been difficult due in part to complications arising from the chemical lability of the positi...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Biochemistry
Main Authors: Kou, Yi, Koag, Myong-Chul, Lee, Seongmin
Format: Artigo
Jezik:Inglês
Izdano: 2018
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6113087/
https://ncbi.nlm.nih.gov/pubmed/29957995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.8b00331
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